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Mengekspresikan. 5 I will take this on board An alternative to “well noted” that is used almost exclusively in a business setting is the phrase “I will take this on board” To take something on board is defined by Oxford Languages as to “fully consider or assimilate a new idea or situation”.

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MechanismRegulation of Gene ExpressionMeasurementExpression SystemGene NetworksTechniques and ToolsGene Expression DatabasesTranscription The production of a RNA copy from a DNA strand is called transcription and is performed by RNA polymerases which add one ribonucleotide at a time to a growing RNA strand as per the complementarity law of the nucleotide bases This RNA is complementary to the template 3′ → 5′ DNA strand with the exception that thymines (T) are replaced with uracils(U) in the RNA In prokaryotes transcription is carried out by a single type of RNA polymerase which needs to bind a DNA sequence called a Prib mRNA processing While transcription of prokaryotic proteincoding genes creates messenger RNA (mRNA) that is ready for translation into protein transcription of eukaryotic genes leaves a primary transcript of RNA (preRNA) which first has to undergo a series of modifications to become a mature RNA Types and steps involved in the maturation processes vary between coding and noncoding preRNAs ie even though preRNA molecules for both mRNA and tRNA undergo splicing the steps and machinery involved are di Noncoding RNA maturation In most organisms noncoding genes (ncRNA) are transcribed as precursors that undergo further processing In the case of ribosomal RNAs (rRNA) they are often transcribed as a prerRNA that contains one or more rRNAs The prerRNA is cleaved and modified (2′Omethylation and pseudouridine formation) at specific sites by approximately 150 different small nucleolusrestricted RNA species called snoRNAs SnoRNAs associate with proteins forming snoRNPs While snoRNA part basepair with the targ Regulation of gene expression is the control of the amount and timing of appearance of the functional product of a gene Control of expression is vital to allow a cell to produce the gene products it needs when it needs them in turn this gives cells the flexibility to adapt to a variable environment external signals damage to the cell and other stimuli More generally gene regulation gives the cell control over all structure and function and is the basis for cellular differentiation morphogenesisand the versatility and adaptability of any organism Numerous terms are used to describe types of genes depending on how they are regulated these include 1 A constitutive geneis a gene that is transcribed continually as opposed to a facultative gene which is only transcribed when needed 2 A housekeeping gene is a gene that is required to maintain basic cellular function and so is typically expressed in all cell types of an organism Examples include actin GAPDH and ubiquitin Measuring gene expression is an important part of many life sciences as the ability to quantify the level at which a particular gene is expressed within a cell tissue or organism can provide a lot of valuable information For example measuring gene expression can 1 Identify viral infection of a cell (viral proteinexpression) 2 Determine an individual&#39s susceptibility to cancer (oncogeneexpression) 3 Find if a bacterium is resistant to penicillin (betalactamaseexpression) Similarly the analysis of the location of protein expression is a powerful tool and this can be done on an organismal or cellular scale Investigation of localization is particularly important for the study of development in multicellular organisms and as an indicator of protein function in single cells Ideally measurement of expression is done by detecting the final gene product (for many genes this is the protein) however it is often easier to detect one of the precursors typically mRNAand to in An expression system is a system specifically designed for the production of a gene product of choice This is normally a protein although may also be RNA such as tRNA or a ribozyme An expression system consists of a gene normally encoded by DNA and the molecular machinery required to transcribe the DNA into mRNA and translate the mRNA into proteinusing the reagents provided In the broadest sense this includes every living cell but the term is more normally used to refer to expression as a laboratory tool An expression system is therefore often artificial in some manner Expression systems are however a fundamentally natural process Viruses are an excellent example where they replicate by using the host cell as an expression system for the viral proteins and genome Genes have sometimes been regarded as nodes in a network with inputs being proteins such as transcription factors and outputs being the level of gene expression The node itself performs a function and the operation of these functions have been interpreted as performing a kind of information processingwithin cells and determines cellular behavior Gene networks can also be constructed without formulating an explicit causal model This is often the case when assembling networks from large expression data sets Covariation and correlation of expression is computed across a large sample of cases and measurements (often transcriptome or proteome data) The source of variation can be either experimental or natural (observational) There are several ways to construct gene expression networks but one common approach is to compute a matrix of all pairwise correlations of expression across conditions time points or individuals and convert the matrix (after thresholding at some cutoff The following experimental techniques are used to measure gene expression and are listed in roughly chronological order starting with the older more established technologies They are divided into two groups based on their degree of multiplexity 1 Lowtomidplex techniques 11 Reporter gene 12 Northern blot 13 Western blot 14 Fluorescent in situ hybridization 15 Reverse transcription PCR 2 Higherplex techniques 21 SAGE 22 DNA microarray 23 Tiling array 24 RNASeq Gene expression omnibus (GEO) at NCBIExpression Atlas at the EBIMouse Gene Expression Database at the Jackson Laboratory.

Gene expression Wikipedia

mengekspresikan [mengekspresikan] Kata Verbia (kata kerja) Dari kata dasar ekspresi Arti mengungkapkan (gagasan maksud perasaan dan sebagainya) dengan gerak anggota badan air muka katakata dan sebagainya contoh &#39ia berusaha mengekspresikan maksudnya dengan gerakan tangannya&#39.

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